Great Baseball Nicknames: ‘ Big Poison’ and ‘Little Poison’- Paul and Lloyd Waner. Brothers Paul ‘Big Poison’ and Lloyd ‘Little Poison’ Waner played together in the Pittsburgh Pirates outfield from 1927-`1940. Both the Waner brothers are in the Baseball Hall of Fame. Paul is a legitimate Hall of Fame selection- he was ‘Big Poison’ not because of his size he was 5’8 152 – but because of his greater power as a hitter. Lloyd ‘Little Poison’ Waner is always listed when they speak of players in the Hall of Fame who were questionable picks. Lloyd was more of a singles hitter- he was actually an inch taller than his brother Paul.